Figure 1: Model of cellular senescence maintained by concerted action of several autocrine self-regulatory loops and the DNA damage response. Although still preliminary, the involvement of ...

A team led by Prof. Wuran Wei from West China Hospital of Sichuan University and Dr. Dechao Feng from the Division of Surgery ...

Cellular aging involves growth arrest and epigenetic alterations, offering insights into therapeutic approaches for enhancing ...

New findings show that the mitochondria powering our cells also control the ability of a DNA repair protein to suppress the senescence-associated secretory phenotype (SASP), which causes zombie-like ...

Certain factors can cause cells to abandon this characteristic and enter a zombie-like state known as senescence where they ... also control the ability of a DNA repair protein to suppress SASP ...

But as they age, they accumulate more and more DNA damage. Until now, it has been unclear why the cell's repair mechanisms do not fix the damage. Researchers led by Melina Schuh and Ninadini ...

Despite the higher levels of DNA damage in polyploid cells, they showed greater resistance to cisplatin than diploid cells.

When they get too short, the DNA has less protection and is prone to damage. Eventually, telomere shortening leads to cell senescence. Senescent cells are not capable of dividing and no longer ...

At this point, DNA repair systems recognize it as DNA damage and trigger a form of permanent cell cycle arrest called replicative senescence, which may lead to cell death called apoptosis. 5 This ...

Proteins that trigger cell senescence occupy much of the literature on aging, but a small RNA moves into the limelight. Kamal is a freelance science journalist based in the UK with a PhD in virology ...