Therefore, chromatin is further coiled into an ... the packing ratio of DNA in metaphase chromosomes is approximately 10,000:1 (depending on the chromosome). This can be thought of as akin to ...

Together, eukaryotic DNA and the histone proteins that hold it together in a coiled form is called chromatin ... then arranged into structures called chromosomes. Chromosomes take different ...

Among the many marvels of life is the cell's ability to divide and thus enable organisms to grow and renew themselves. For ...

This coiling causes the chromosome to resemble a spring. Chromatin refers to proteins that help organize the long DNA molecule. The protein shown here supports and organizes small loops of DNA.

Scientists at EMBL have captured how human chromosomes fold into their signature rod shape during cell division, using a ...

It must be compatible with the high concentration of DNA and the elongated cylindrical shape of chromosomes and the known self-associative properties of chromatin, and also with an effective ...

Chromosomes also play a role in regulating gene expression. The structure and packaging of chromatin can influence which genes are active or silenced in a particular cell type or developmental stage.

DNA methylation is a key factor in the regulation of organismal development and tissue homeostasis. DNA methylation marks indicate how to regulate ...

demonstrated that chromosome segregation errors alter the shape of the nucleus as well as its mechanical properties. The shape and mechanics of the nucleus are known to be influenced by internal ...

So, it's very easy to see,” she said. To zoom in on changes in chromosome organization during meiosis, the researchers used nuclear membrane and DNA damage protein stains to track nuclear behavior.

To do so, they planned to stabilize proteins at their chromatin binding locations and use nucleic acid hybridization to fish out specific DNA sequences along with the bound proteins. By using enzymes ...