Adoptive transfer of autologous dendritic cells (DC) presenting tumor-associated antigens initiate and sustain an immune response which eradicate murine malignancies. Based on these observations ...

Recently, DC-based cancer vaccines have attracted considerable attention as vehicles for the delivery of tumor-associated antigens, chemokines and cytokines. 4,30 In this study, our DC-hgp100/mIL ...

DC-ATA was produced by incubating DC with an ATA lysate prepared from irradiated self-renewing tumor cells. Just prior to each treatment, DC-ATA or MC was admixed in 500 mg GM-CSF and injected s.c. at ...

Our group has developed four groups of strategies to enhance uniform targeting of the antigenically heterogenous cancer cells and to eliminate the “cold” tumor phenotypes: 1) Cell-based ...

The antigen source may be derived from peptides such as shared or neoantigens, or from various cellular components of the tumor. Cell-based vaccines are generated by loading antigens onto ex ...

Despite the role of tumor mutational burden in immunotherapy response, DC gene signatures are more indicative of T cell inflammation in tumors. This highlights the critical role of antigen ...

Some examples are vaccines against breast cancer (the HER2 antigen), 82–84 B-cell lymphoma (the tumor immunoglobulin idiotype), 85 lung cancer (the MUC1 antigen), 86 melanoma (dendritic cells ...

The immediate goal is to create vaccines that destroy cancer cells—but some scientists are also testing vaccines that might prevent someone from developing cancer. SCIENCE Here’s how they work.

The cancer vaccine also delivers mRNA in tiny bubbles, but the mRNA codes for antigens found in cancer cells, and the bubbles, called lipid nanoparticles, ...

India's first indigenous tumour antigen SPAG9 was discovered in 1998 by Dr Anil Suri who heads the Cancer Research Programme at the NII, a DBT institute. Press Trust of India India News ...

Mayo Clinic researchers have discovered a new immunotherapy target, a cryptic antigen, that may be key in helping the immune ...