A number of cell surface and nuclear receptors mediate their actions via dimerization. While this has been well established, the dimerization of G-protein coupled receptors (GPCRs) (that ...

The study specifically examines two types of GPCRs expressed on astrocytes: dopamine D1 receptors (D1R) and metabotropic glutamate receptor 5 (mGLUR5). These receptors respond to various ligands, ...

The study specifically examines two types of GPCRs expressed on astrocytes: dopamine D1 receptors (D1R) and metabotropic glutamate receptor 5 (mGLUR5). These receptors respond to various ligands ...

Dopamine’s effects in the brain are mediated by postsynaptic D1 and D2 receptors. Adenosine A1 and A2A receptors are uniquely positioned to counteract the excessive stimulation of dopamine receptors ...

The 2012 Nobel Prize for Chemistry has been awarded to Robert Lefkowitz and Brian Kobilka for groundbreaking discoveries that reveal the inner workings of G-protein-coupled receptors. Professor David ...