The second component is TadA8e, an adenine deaminase for facilitating A-to-G conversion. The third component, DddA tox, is a cytosine deaminase that makes the DNA more accessible to TadA8e.

Programmable deaminases, which consist of a custom DNA-binding protein and a nucleobase deaminase ... genome editing: cytosine base editors and adenine base editors, such as DddA-derived cytosine ...

Recently, a new tool for mitochondrial DNA mutagenesis has emerged—the double-stranded DNA deaminase (DddA)-derived cytosine base editor (DdCBE). A new study tested the base editor for in vivo ...

The base editors are fusions of a nickase-type Cas9 protein with a cytosine deaminase or an adenine deaminase, and have been found to catalyze the conversion of either C>T or A>G in the target ...