Figure 4: The tyrocidine synthetase thioesterase domain (TycC TE) catalyses dimerization of the pentapeptide-SNAC GLP5 and cyclization of the resulting decapeptide-SNAC to form gramicidin S.

CβG biosynthesis is catalyzed by cyclic β-1,2-glucan synthase (CGS), an enzyme that catalyzes the cyclization (closed ring formation) of linear β-1,2-glucan (LβG). Since the method for large ...

Scientists have developed a new method to synthesize and screen thousands of macrocyclic compounds, a family of chemicals that are of great interest in the pharmaceutical industry. Macrocyclic ...