The tiny protein known as transthyretin can cause big problems in the body when it misfolds after secretion. While healthy ...

The crystal structure of a second G protein–coupled receptor sheds light on these key pharmaceutical targets. In contrast, β2AR and essentially all of the other GPCRs are present at very low ...

his algorithms can even advise researchers which bits of a protein to truncate to boost chances of getting a crystal structure. He is making plans to undertake a similar project for membrane ...

These insights could drive the development of new drugs to treat transthyretin amyloidosis, a progressive and fatal disease.

View Full Profile. Learn about our Editorial Policies. While AlphaFold and the subsequent AI revolution in biology garnered a lot of attention, the foundational bricks for the strides made in protein ...

Biological scientists have uncovered how the dengue virus uses its envelope protein to capture human plasmin from a blood meal to enhance the permeability of the mosquito midgut for infection.

Researchers have uncovered how the dengue virus uses its envelope protein to hijack human plasmin to enhance transmission.

After translation, the polypeptide is finally folded into the correct shape and becomes a protein. Peptide bonds form between the adjacent amino acids to finalise the structure.

Insights into the structures could lead to improved treatment strategies for transthyretin amyloidosis, a progressive, fatal disease in men.