Objectives/methods Using a specially designed functional MRI (fMRI) cycling ergometer, we have determined the sequence in which the cortical and subcortical brain regions are modulated at low and high ...

Seizures may occur, usually late in the course. Cognitive decline/dementia is of subcortical vascular type with impaired executive and organizing functions, general mental and psychomotor slowing ...

is the most common hereditary subcortical vascular dementia. It is caused by the defective NOTCH3 gene, which encodes a transmembrane receptor; over 170 different mutations are known. The main ...