Here, we review recent advances in how COPII vesicle formation and cargo export in mammals is regulated, and how these regulatory mechanisms are relevant to human physiology and disease.

CPCs — which include the COPII, clathrin and COPI coats ... and structural model of coat function in the formation and fission of vesicles and tubules in endomembrane traffic.

"Also, COPII selects the appropriate fusion machinery ... In order to understand the process of vesicle formation and transport in molecular terms, one must begin with the initiating event ...

Important to this process is a special protein coat, the COPII complex, that helps in concentrating the cargo at the ER and budding off the small vesicles that are consequently called COPII-coated ...

Although many studies have shown how these vesicles, called COPII carriers ... that led the team to examine the role of USP8 in the formation of COPII carriers. In research tracing back more ...

Proteins enriched in intrinsically disordered regions (IDRs) can drive membrane curvature formation in artificial ... structures co-localized with COPII vesicle markers, forming COPII-like ...

(Nanowerk News) Engineers at Carnegie Mellon University and biomedical researchers at the University of Pittsburgh and Magee-Womens Research Institute have established a framework for understanding ...

A framework for understanding the mechanics that underlie vesicle formation has been established by engineers at Carnegie Mellon University and biomedical researchers at the University of ...

However, the formation of membrane vesicles by bacteria is currently not well understood. In particular, the release mechanism of membrane vesicles of Gram-positive bacteria, which have a very ...

So it’s not all slow endocytosis, and vesicle formation is not all clathrin. The new study adds another layer of complexity to our understanding of the synapse and how neuronal communication ...