4a) were similar to those for template A (Fig. 2a). Figure 4: Conformational profiles depend on the templating base. Whereas the unliganded wt KF, E710A and E710Q polymerases exhibit similar ...

However, when testing a hydrogenated derivative – specifically 18,19-dihydro salinomycin – they managed to replace a C–H bond ...

In biology, enzymes have evolved over millions of years to drive chemical reactions. Scientists from the Max Planck Institute ...

Researchers led by Université de Montréal pathology and cell-biology professor Marc Therrien have identified major structural ...

as well as ionizable functional groups effecting successful cell permeability. PCA (Protein Conformational Array) technology can quantify conformational change by measuring protein surface epitope ...

In biology, enzymes have evolved over millions of years to drive chemical reactions. Scientists have now derived universal rules to enable the de novo design of optimal enzymes. As an example, they ...

In biology, enzymes have evolved over millions of years to drive chemical reactions. Scientists from the Max Planck Institute ...

The parameters that can be determined include the following: The Zetasizer Helix (ZS Helix) from Malvern Panalytical combines a fiber-coupled Raman spectrometer with a Zetasizer Nano ZSP to provide ...

Recently, a research team has collaborated to propose a deep learning model for predicting protein conformational changes. This achievement has been published online in Advanced Science.

Study: Prefusion Spike Protein Conformational Changes Are Slower in SARS-CoV-2 than in SARS-CoV-1. Image Credit: 168 STUDIO / Shutterstock.com Although several studies have shown that the ...

Conformational changes must take place in the viral glycoprotein spikes to allow its hydrophobic fusion domain to be inserted into the host cell membrane. These conformational changes serve as a ...