4a) were similar to those for template A (Fig. 2a). Figure 4: Conformational profiles depend on the templating base. Whereas the unliganded wt KF, E710A and E710Q polymerases exhibit similar ...

In biology, enzymes have evolved over millions of years to drive chemical reactions. Scientists from the Max Planck Institute ...

In biology, enzymes have evolved over millions of years to drive chemical reactions. Scientists from the Max Planck Institute ...

In biology, enzymes have evolved over millions of years to drive chemical reactions. Scientists have now derived universal rules to enable the de novo design of optimal enzymes. As an example, they ...

as well as ionizable functional groups effecting successful cell permeability. PCA (Protein Conformational Array) technology can quantify conformational change by measuring protein surface epitope ...

Conformational changes in proteins, which occur at the nanoscale, are fundamental to processes ranging from enzyme catalysis and chemical signaling to cell division and differentiation.

Unlike chemical reactions, biomolecular conformational changes, such as protein folding or binding to other molecules, involve multiple metastable intermediate states, giving rise to numerous ...

Recently, a research team has collaborated to propose a deep learning model for predicting protein conformational changes. This achievement has been published online in Advanced Science.

The parameters that can be determined include the following: The Zetasizer Helix (ZS Helix) from Malvern Panalytical combines a fiber-coupled Raman spectrometer with a Zetasizer Nano ZSP to provide ...

Researchers have revealed the mechanism underlying GPCR function using a GPS nuclear magnetic resonance (NMR) technique.

Conformational changes must take place in the viral glycoprotein spikes to allow its hydrophobic fusion domain to be inserted into the host cell membrane. These conformational changes serve as a ...