STAG2 protein mutations and associated spatial alteration of DNA structure can contribute ...
In myeloid leukemias, mutations in the cohesin subunit STAG2 are particularly common, while those in STAG1 are almost never ...
EurekAlert!2 个月
DNA being folded into a loop by an SMC motor called cohesin (in purple/blue). (IMAGE)
The illustration shows DNA being folded into a loop by an SMC motor called cohesin (in purple/blue). The purple part of the motor (with a red/green label) is the protein subunit NIPBL, which acts ...
来自MSN2 个月
DNA motors can switch direction, reshaping genetic understanding
We even identified the 'gear lever," protein subunit NIPBL, in the cohesin SMC motor protein." To discover the reverse gear of SMC motors, the researchers used an advanced home-built microscope to ...