Figure 1: Top1, Top3 and Smc5/6 are required for timely completion of replication on long chromosomes. Figure 3: The Smc5/6 complex senses chromosome length and circularization of Chr III.

However, we found that DNA synthesis could be detected on these delayed chromosomes during mitosis, suggesting that these cells either escaped or adapted from the DNA replication checkpoint.

The initiation of chromosome replication is exquisitely regulated in both time and location. It has been estimated that there are 200-400 autosomal replication sequence elements (ARSs) in the yeast ...

(PhysOrg.com) -- A novel study from Karolinska Institutet has deepened the understanding of how chromosome replication, one of life's most fundamental processes, works. In a long term perspective ...

A novel study from the Swedish medical university Karolinska Institutet has deepened the understanding of how chromosome replication, one of life's most fundamental processes, works. In a long ...

Unlike shoelaces, though, chromosomes replicate themselves from time to time as the cells they are in divide. This shortens the telomere and, after 50-70 such divisions (a number known as the ...

The human genetic blueprint is deceptively simple. Our genes are tightly wound into 46 X-shaped structures called chromosomes. Crafted by evolution, they carry DNA and replicate when cells divide, ...

Our lab studies the mechanism of eukaryotic chromosome replication. Chromosomes are the carriers of the genetic and epigenetic information and faithful chromosome replication is of fundamental ...

Your chromosomes are how your cells store your DNA. They also help ensure the accurate copying of DNA during cell replication. This DNA is grouped into segments called genes. Your genes determine ...

Our lab studies the mechanism of eukaryotic chromosome replication. Chromosomes are the carriers of the genetic and epigenetic information and faithful chromosome replication is of fundamental ...

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