Figure 1: Top1, Top3 and Smc5/6 are required for timely completion of replication on long chromosomes. Figure 3: The Smc5/6 complex senses chromosome length and circularization of Chr III.

However, we found that DNA synthesis could be detected on these delayed chromosomes during mitosis, suggesting that these cells either escaped or adapted from the DNA replication checkpoint.

A novel study from the Swedish medical university Karolinska Institutet has deepened the understanding of how chromosome replication, one of life's most fundamental processes, works. In a long ...

Unlike shoelaces, though, chromosomes replicate themselves from time to time as the cells they are in divide. This shortens the telomere and, after 50-70 such divisions (a number known as the ...

Our lab studies the mechanism of eukaryotic chromosome replication. Chromosomes are the carriers of the genetic and epigenetic information and faithful chromosome replication is of fundamental ...

The initiation of chromosome replication is exquisitely regulated in both time and location. It has been estimated that there are 200-400 autosomal replication sequence elements (ARSs) in the yeast ...

(PhysOrg.com) -- A novel study from Karolinska Institutet has deepened the understanding of how chromosome replication, one of life's most fundamental processes, works. In a long term perspective ...

Our lab studies the mechanism of eukaryotic chromosome replication. Chromosomes are the carriers of the genetic and epigenetic information and faithful chromosome replication is of fundamental ...

The human genetic blueprint is deceptively simple. Our genes are tightly wound into 46 X-shaped structures called chromosomes. Crafted by evolution, they carry DNA and replicate when cells divide, ...

Cancer is the result of many accumulated mutations that allow a cell to replicate out of control. Y-chromosome loss is one big glaring mutation. Perry suggests both could be the result of some ...

Your chromosomes are how your cells store your DNA. They also help ensure the accurate copying of DNA during cell replication. This DNA is grouped into segments called genes. Your genes determine ...

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