The improper segregation of chromosomes during cell division leads to abnormalities that disrupt the proper functioning of ...

In the latest PNAS paper 2, aneuploidy as the functional genetic basis of cancer passes both these tests in ways that should be of interest to biotechnologists of a variety of stripes. Of all the ...

Aneuploidy—when the cells of an organism contain more or fewer than the standard number of chromosomes for its species—is found in greater than 90 percent of all human cancers. But how exactly it ...

(See illustration on opposite page.) Errors in chromosome segregation propagate and multiply. This results in a population of cancer cells with a vast amount of heterogeneity in their chromosomal ...

Translocations generate novel chromosomes, but are often linked to disorders like infertility and cancer. How do these new chromosomes generate problems, and how are they detected? Translocations ...

Since aneuploidy slows down the growth of healthy cells and often leads to cell death, a key question in cancer research is: why and how are cancer cells with this genetic burden able not only to ...

Problems in kinetochore-microtubule attachment and chromosome segregation can lead to aneuploidy, which is associated with birth defects and cancer progression. Kinetochore capture by spindle ...

Since aneuploidy slows down the growth of healthy cells and often leads to cell death, a key question in cancer research is: why and how are cancer cells with this genetic burden able not only to ...

Since aneuploidy slows down the growth of healthy cells and often leads to cell death, a key question in cancer research is: why and how are cancer cells with this genetic burden able not only to ...

However, aneuploidy in healthy cells was considered ... undergone breast reduction surgery and did not have cancer. They profiled the genetic makeup of these women and then used another test ...

Since aneuploidy slows down the growth of healthy cells and often leads to cell death, a key question in cancer research is: why and how are cancer cells with this genetic burden able not only to ...

At the Ben David Lab, his team focuses on an understudied trait of cancer—aneuploidy, the presence of an abnormal number of chromosomes in cancer cells. While this genetic instability is a ...