UBE3A is located on chromosome 15. Mutations that delete the gene or change its structure, function or activity can cause Angelman syndrome. In many cases, a mutation develops spontaneously on the ...

Angelman Syndrome is a rare genetic disorder caused by UBE3A gene mutations, leading to developmental delays, speech issues, ...

The rectangles represent chromosome 15. Hatched chromosomes have a paternal pattern of gene functioning and DNA methylation; open chromosomes have a maternal pattern. Angelman syndrome is caused ...

Down syndrome is caused by a translocation of chromosomes 15 and 21 (Figure 3), in which the long arms of two acrocentric chromosomes are translocated to produce a single long chromosome ...

Created with Sketch. Angelman syndrome is caused by an over-expression of paternal imprinted genes and an under-expression of maternal ones on chromosome 15. Children with this genetic disorder ...