在这样的背景下，美国加利福尼亚大学圣地亚哥分校的研究人员开展了一项关于 DUBR（Dppa2 上游结合 RNA，也称为 linc00883）非编码 RNA 的研究。他们发现 DUBR 在人类结肠癌的发生发展中扮演着重要角色，这一发现为癌症研究开辟了新的道路。该研究成果发表在《Functional & Integrative Genomics》杂志上。

At the time, researchers were unsure whether histones in the nucleosomes dissociated or remained bound to the DNA as the chromatin uncoiled and RNA polymerase began its job transcribing genes. It was ...

Novel technology enables discovery, which could help predict tumour recurrence Researchers from the Fred Hutch Cancer Centre, ...

Single-cell multiomic analyses reveal known and new genes and pathways involved in the development of germ cells and provide a discovery platform for the scientific community.

While it's understood that genes function as a set of instructions for creating RNA, and thus proteins and ... to individually label and observe chromatin fibers: the bundle of DNA and proteins ...

LncRNAs and circRNAs are key regulators of gene expression, influencing disease mechanisms and offering potential as ...

But truly understanding these effects requires a deeper look into chromatin regulation and epigenetic mechanisms. In this GEN webinar, our expert speaker Dave Lahr, PhD, Senior Director of ...

"If we look at the average chromatin structures in human cells and ... of these loops is most likely related to a protein, RNA polymerase, which synthesizes RNA from a DNA template.