为解决头颈部鳞癌（HNSCC）放疗效果不佳问题，英国研究人员开展 Chk1 和 Wee1 激酶抑制剂联合放疗研究，发现可增强 HNSCC 对 X 射线和质子束疗法（PBT）的敏感性，为治疗提供新方向。 头颈部鳞癌（Head and Neck Squamous Cell Carcinoma，HNSCC）是一种常见的恶性肿瘤 ...

Mechanistically, the compound induced cell cycle arrest: in SW-480 and Caco-2 cells, it halted progression at the S phase through the ATR/Chk1 pathway, while in HCT-116 cells, it caused arrest at ...