The chiral-switch concept. Chiral switches are chiral drugs that have already been CLAIMED, approved and marketed as racemates or as mixtures of diastereomers, but have since been redeveloped as ...

Control of molecular chirality improves drug safety Many chemical molecules have two configurations, or chiral versions, that are mirror images of each other. While sharing the same molecular ...

The 2021 Nobel Prize in Chemistry, awarded to Benjamin List and David MacMillan ... to enable the metal-free chemical synthesis of chiral drugs has already been demonstrated (Panel C).

New synthesis strategy for chiral drugs: Versatile chiral chemical species from aldehydes. ScienceDaily. Retrieved June 2, 2025 from www.sciencedaily.com / releases / 2019 / 01 / 190109102435.htm.

Thus, developing a chemical synthesis reaction that selectively produces one enantiomer of chiral molecules useful in medicine is of great significance in the synthesis of drugs and their precursors.

One prominent example of a chiral switch occurred in 2001, when the US Food and Drug Administration (FDA) approved AstraZeneca’s esomeprazole (Nexium), a proton pump inhibitor (PPI) used to ...

Scientists at The Scripps Research Institute (TSRI) say they have invented a new technique for constructing chiral drug molecules, whose structural complexity allows them to have mirror-image ...

Work on existing molecules with proven market by developing chiral molecules of racemates currently marketed, or through new formulations of existing drugs with beneficial characteristics of increased ...

Overall, the development of chiral antitubercular drugs represents an important area of research for the treatment of TB. These drugs have the potential to overcome drug resistance and offer more ...

Researchers have developed a highly efficient way to produce chiral multi-centered fused tricyclic compounds of which core structure is often found in bioactive compounds including medicines. Chemists ...