The aptamer portion of the chimeras mediates binding to PSMA, a cell-surface receptor overexpressed in prostate cancer cells and tumor vascular endothelium, whereas the siRNA portion targets the ...

Prostate cancer cells expressing prostate-specific membrane antigen (PSMA) have been targeted with RNA aptamer–small interfering (si)RNA chimeras, but therapeutic efficacy in vivo was ...

This mythical chimera has been left in the pages of legend. But scientists today are making chimeras of their own, blending together cells from multiple species in a single animal. The term resurfaced ...

These human-pig “chimeras” were not allowed to develop past the fetal stage, but the experiment suggests such creations could eventually be used to grow fully human organs for transplant ...

Some examples of chimeras are already familiar to most people. For instance, tissue chimeras result from organ transplants or tissue transplants (such as a bone marrow transplant). Following the ...

These human-pig “chimeras” were not allowed to develop past the fetal stage, but the experiment suggests such creations could eventually be used to grow fully human organs for transplant ...

The news that researchers want to create human-animal chimeras has generated controversy recently, and may conjure up ideas about Frankenstein-ish experiments. But chimeras aren't always man-made ...

We are, at minimum, several steps and several years away from being able to create fully grown human-animal chimeras. But worries over the ethics of chimera research have been with us since the ...