乳腺癌是全球女性癌症发病和死亡的主要原因，三阴性乳腺癌（TNBC）治疗挑战大。研究人员探究新型查尔酮衍生物 Chalcone-9 对 TNBC 的抗癌活性。结果显示 Chalcone-9 能抑制 JAK-STAT 通路、诱导癌细胞凋亡，是极具潜力的 TNBC 治疗候选药物。

相关研究成果以“Corymbinols A and B: Bis-β-triketone Conjugates of Sesquiterpene and Chalcone from the Fruit of?Corymbia citriodora”为题发表于国际权威期刊Organic Letters（《有机化学通讯》 ） 铜死亡（Cuproptosis）作为近年来新发现的铜依赖程序性 ...

Naringenin chalcone represents an intermediate in the biosynthesis of flavonols and is converted into the next compound in the pathway, naringenin, by the enzyme chalcone isomerase (CHI).

Novel chalcone derivative presents relevant anti-NASH effects. Aug. 29, 2023. No Comments. Nonalcoholic steatohepatitis (NASH) is a progressive form of nonalcoholic fatty liver disease with limited ...

BUFFALO, NY- August 23, 2024 – A new research paper was published in Volume 15 of Genes & Cancer on August 9, 2024, entitled, “Dialyl-sulfide with trans-chalcone prevent breast cancer ...

Home » Discovery of novel quinolone-chalcone derivatives with potent antifungal activity when combined with fluconazole. X. Upgrade your daily dose of biopharma and medtech news. Subscribe to ...

A new research paper was published inGenes & Cancer on August 9, 2024, titled "Dialyl-sulfide with trans-chalcone prevent breast cancer prohibiting SULT1E1 malregulations and oxidant-stress ...

An enzyme called chalcone synthase (CHS) controls the flux towards flavonoid biosynthesis and therefore tricin. In maize, one of the main genes to encode for this enzyme is Colorless2 (C2).