The authors propose that ceramide, possibly thanks to its cone-shaped structure, induces inward budding of endosomes to produce ILVs that are subsequently secreted as exosomes.

Kong’s research, titled “Sensing ceramides by CYSLTR2 and P2RY6 to ... CYSLTR2 and P2RY6 for ceramides and uncovered the molecular mechanism where ceramides exacerbate atherosclerosis and ...