An MTF2-containing subcomplex of Polycomb Repressive Complex 2 promotes cell cycle progression through repression of D-type cyclin expression in certain cellular contexts.

leading to cell cycle arrest in the G1 phase. Further investigation into the role of CDK4/CDK6 in ESCC was conducted through CRISPR-mediated gene knockout experiments. The depletion of CDK4/CDK6 ...

This study presents fundamental insights into overcoming resistance in hormone receptor-positive breast cancer by demonstrating that sustained CDK4/6 inhibitor treatment, either alone or in ...

PHEC-66's impact extends to the modulation of cell cycle progression, particularly evident in the sub G1 and sub G1/G1 phases ...