BAD is a pro-apoptotic member of the Bcl-2 family that is tightly regulated by survival factors. Several major signalling pathways influence cell death through their direct effects on the ...

Melanoma, one of the most aggressive forms of skin cancer, often metastasizes to bones, causing severe bone loss, an increased risk of fractures, and significant pain. Bone metastasis is associated ...

Figure 1: The signalling pathway by which insulin inhibits GSK3 ... studies that had implicated GSK3 in the regulation of cell survival 53. These observations indicate that GSK3 inhibitors might ...

Autophagy, the cell's essential housekeeping process, involves degrading and recycling damaged organelles, proteins, and other components to prevent clutter. This vital mechanism, found in all life ...

Dark zone lymphoma includes aggressive B-cell lymphomas with shared molecular features. While some respond to escalated ...

Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA. Caenorhabditis elegans drp-1 and fis-2 Regulate Distinct Cell-Death Execution Pathways Downstream of ced-3 and ...

Metabolic pathways are integrated and controlled enzyme-catalysed reactions within a cell. In animals, specific metabolic pathways can produce vitamins and haemoglobin. Metabolic pathways can be ...

Enzymes are vital proteins involved in metabolic pathways. Some enzymes can be found embedded within the cell membrane. Other proteins found embedded within the membrane act as: pumps - for ...

The researcher has given an overview on the regulatory network of extracellular circRNAs in cancer and their impact on cancer drug resistance. In order to propagate malignancy, circRNAs shuttle ...

New study successfully made CTC-derived organoids from breast cancer patients' blood samples to investigate cell survival and ...