Exosomal mRNA transfer from non-neuronal cells to neurons under hypoxia drives hemoglobin expression and preserves mitochondrial homeostasis as an intercellular protective mechanism.

Comprehensive single-cell transcriptomic analysis revealed that in the animals treated with the advanced reperfusion technology, genes encoding proteins involved in oxidative injury, stress ...

Activation of the PHD–HIF pathway promotes the resolution of mucosal inflammation in mice. 48 Hypoxia-induced changes in gene expression by epithelial cells help to promote mucosal barrier ...

Cellular energy production. Nutrients, such as glucose and fatty acids, as well as oxygen, enter the cell across the cell membrane. Hypoxic injury results in an inadequate flow of nutrients and oxygen ...

Researchers at the University of California, San Diego School of Medicine have identified a critical metabolic "switch" in fruit flies that helps oxygen-deprived cells survive. Hypoxia-induced ...

Hypoxia refers to tissues or cells having too little oxygen to function correctly. ... Hypoxia most commonly results from lung conditions but may stem from a heart or liver condition or an injury.

As expected, the scientists saw gene-expression changes after 24 and 48 hours in genes known to respond to hypoxia. They also saw changes in a group of genes expressed in the subventricular zone, an ...

If you have hypoxic or anoxic brain injury, it could put you in a coma. When that happens, it looks like you’re asleep and you won’t respond if you’re called or stimulated in some way.

The finding has implications for treating sickle cell disease and beta-thalassemia, according to the scientists who published their study “Activation of γ-globin expression by hypoxia-inducible ...