Cell death is achieved by two fundamentally different mechanisms: apoptosis and necrosis. Apoptosis is dependent on caspase activation, whereas the caspase-independent necrotic signaling pathway ...

Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA. Caenorhabditis elegans drp-1 and fis-2 Regulate Distinct Cell-Death Execution Pathways Downstream of ced-3 and ...

Members of the program engage in research aimed at obtaining a mechanistic understanding of signal transduction and cellular regulation, which includes cellular signaling pathways and downstream ...

My group focuses on understanding cell signaling pathways primarily linked with the ubiquitin and autophagy systems and frequently altered in diseases, including neurodegenerative disease. To this end ...

A new review was published as the cover paper of Aging, titled "Types of cell death and their relations to host immunological pathways." Various immune pathways in the host, such as TH1 ...

Various immune pathways in the host, such as TH1, TH2, TH3, TH9, TH17, TH22, TH1-like, and THαβ, have been identified. While ...

This is important because some forms of cell death are unnoticed by the immune ... (which the immune system had not previously noticed), signaling that the cancer needs to be destroyed.

Credit: Amgen “The chemists here call mutated KRAS the Death Star,” says Rusty Lipford ... mutant proteins that function in specific signaling pathways that cancer cells rely on—a step ...

This jump-starts signaling pathways inside the cell that spur the production of reactive oxygen species ... bind bacterial effectors and set off secondary immune cascades that boost the PAMP-triggered ...

The researchers found that changes in biochemical signaling pathways occur in the vascular cells during the development of atherosclerosis. "As a cell grows into the plaque and stiffens ...

N4BP1 coordinates ubiquitin-dependent crosstalk within the IκB kinase family to limit Toll-like receptor signaling and inflammation. Immunity. 2024 May 14;57(5):973-986.e7. doi: ...