The irreversibility of cell-cycle transitions is often attributed to the thermodynamic irreversibility of protein degradation 2,7,8,9,10. A mechanical model of dynamic irreversibility ...

Where and when do cyclins act on the cell cycle? (A) Cycling cells undergo three major transitions during their cell cycle. The beginning of S phase is marked by the onset of DNA replication ...

Projects work toward the development of novel drug and cell therapy for the treatment of demyelinating diseases such as Multiple Sclerosis (MS) and myelin diseases of children such as leukodystrophies ...