Medscape1 年
Defining the COX Inhibitor Selectivity of NSAIDs: Implications for Understanding Toxicity
All NSAIDs variably inhibit COX-1 and COX-2 and the mechanisms of inhibition fall ... a potent time-dependent inhibitor of COX-2, whereas celecoxib exhibits slow competitive binding and, at ...
Medscape5 天
Are Selective Cyclo-oxygenase 2 Inhibitors Safe After Coronary Artery Bypass Grafting Surgery
Controversy about the mechanisms of potential cardiovascular ... might increase blood pressure to a greater extent than celecoxib and NSAIDs. Blood-pressure and cardiovascular-safety data on ...