前列腺癌(PC)的治疗面临肿瘤微环境(TME)中肿瘤相关巨噬细胞(M2-TAMs)介导的耐药和转移难题。Sharjah大学团队开发了透明质酸(HA)功能化的壳聚糖纳米球(HA-MTX-ZA-CS-NPs)，通过CD44受体靶向PC细胞和TAMs，实现160 nm粒径、0.453 PDI的稳定载药系统，体外验证其协同抑制肿瘤生长和转移的潜力，为PC治疗提供新型双 ...

为解决 5 - 氟尿嘧啶（5-FU）血浆半衰期短、生物利用度低和毒性高的临床局限，研究人员开展功能性修饰的 5 - 氟尿嘧啶透明质酸微球（PAR-HA Mps/5-Fu）研究。结果显示该微球能靶向结肠释药，安全性好，为结肠癌治疗带来新希望。

徐州医科大学附属医院的研究者们揭示了linc01594-celf6-cd44轴可能作为结直肠癌的生物标记物和治疗靶点. 来源：生物谷原创 2023-07-27 16:31 ...

Nature Communications: CD44与血管内皮细胞自噬功能下降和衰老有关. 来源：生物谷原创 2023-09-12 13:56. 内皮细胞是血管的重要组成部分，在循环血液和组织 ...

Crystals of mouse Cd44-HA complex show two conformations. We have solved three new structures of the murine Cd44 HABD (residues 25–174; mouse Cd44 25–174): the unliganded apoprotein and two HA ...

想象一下，一位年过六旬的张阿姨，多年来饱受多发性骨髓瘤的折磨。化疗药物虽然能暂时控制病情，但癌细胞总是卷土重来，对药物的耐药性也越来越强。如果有一天，我们能通过靶向CD44，打破癌细胞与骨髓微环境的“勾结”，让癌细胞失去“隐形翅膀”，无法在骨髓中“为所欲为”，那对像张阿姨这样的患者来说，无疑是带来了希望的曙光。

This collection of findings led the Duke team to hypothesize that in IPF, interactions between HA and CD44 may similarly drive the process by which fibroblasts develop an aggressive phenotype ...

In univariate analysis, CD44 expression and normal N-myc were the most powerful markers of favorable clinical outcome (P < 10(-6) and chi 2 = 65.40 and P < 10(-6) and chi 2 = 42.56, respectively), but ...

To determine the expression of the CD44 variant containing a variant exon 8 to 10 product (CD44v8-10) in colorectal cancer and to evaluate its prognostic value. Materials and Methods. CD44v8-10 was ...

Researchers investigating the role of the protein CD44 in obesity and metabolic health found that CD44-deficient mice stayed lean even on a high-fat diet, while the control mice developed obesity.

Surprising findings from a study in The American Journal of Pathology show that mice with a CD44 protein deficiency stay lean, despite being on a high-fat diet Researchers investigating the role of ...