Caspase-1 triggers programmed necrosis called pyroptosis by gasdermin-D (GSDMD) cleavage. GSDMD-deficient cells are, however, susceptible to caspase-1-mediated cell death. Researchers at Kanazawa ...

Caspase-1 triggers programmed necrosis called pyroptosis by gasdermin-D (GSDMD) cleavage. GSDMD-deficient cells are, however, susceptible to caspase-1-mediated cell death. Researchers at Kanazawa ...

Inflammasomes are assemblies that are central to inflammatory responses. Now researchers shed new light on function of caspase 12. They have rid the field of a stubborn dogma, which held that ...

Aberrant caspase signalling is implicated in Alzheimer’s disease. Pozueta et al.study a mouse model of Alzheimer’s disease that is deficient in caspase-2 and find that surprisingly, these mice ...

Study: Caspase-4/11 exacerbates disease severity in SARS-CoV-2 infection by promoting inflammation and thrombosis. Image Credit: Kateryna Kon/ Shutterstock This news article was a review of a ...

Researchers have discovered in a new research that oral administration of icariin at a dose of 100 mg/kg demonstrated ...

The significance of research into caspase activity Recent years have seen a rapid emergence of new information on the molecular mechanisms that control caspase activation.

After treated with gentiopicroside, levels of Bax and caspase 3 were increased, and the level of Bcl2 was reduced by in vitro cell culture. Furthermore, gentiopicroside increased levels of Bax and ...