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5 天
光控RNA腺苷碱基编辑器(PA-rABE)的工程化构建及其在体内基因治疗中 ...
基因治疗领域亟需可调控、可逆的基因表达工具。研究人员通过整合微型Cas13变体与光诱导二聚化的Magnets系统,开发出光激活RNA腺苷碱基编辑器(PA-rABE)。该系统在蓝光照射下实现ADAR2脱氨酶的高效组装,对内源RNA进行精准编辑(如CTNNB1基因磷酸化位点),稳定 ...
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