Scientists removed unnecessary sections of the Cas13 enzyme, ... by carving out unnecessary bits and then using an artificial intelligence platform called AlphaFold2 to visualize the structure of ...

CRISPR–Cas13 can rectify unusual splicing events. Demethylase is an enzyme that plays a crucial role in post-transcriptional modification ... and the secondary structure of the RNA molecule.

RNA gene scissors (CRISPR-Cas13) are gaining significant attention as a next-generation gene therapy with fewer side effects. They can suppress infection by eliminating viral RNA, such as in ...

CRISPR–Cas13 can rectify unusual splicing events.Demethylase is an enzyme that plays a crucial role in post-transcriptional modification (PTM), a process that occurs after transcription and ...

To create REPAIR, the researchers systematically profiled the CRISPR-Cas13 enzyme family for potential “editor” candidates. (Unlike Cas9, the Cas13 proteins target and cut RNA; see infographic in ...

Unlike Cas13, Cas7-11 can precisely edit RNA strands. It was already known that Cas7-11 is a combination of five different enzymes, so the researchers used cryo-electron microscopy to study the ...

However, most RNA-targeting Cas13 proteins function at around 37 degrees Celsius, which is incompatible with RT-LAMP. The team wanted to find a Cas13 enzyme that targets viral RNA and is stable at ...