诺奖团队最新Science论文：利用AlphaFold2发现Cas13的祖先，并解析其结构和功能. 来源：生物世界 2024-07-29 11:00. 在这项研究中，研究团队构建了一个 ...

Feiyu Zhao et al. A strategy for Cas13 miniaturization based on the structure and AlphaFold. Nature Communications, 2023, doi:10.1038/ s41467-023-41320-8.

这些研究人员利用了一种最近描述过的称为Cas13的酶，该酶靶向RNA而不是DNA。通过使用Cas13，他们设计了一个优化平台，用于在人细胞中在RNA水平上大 ...

李占军教授在一封电子邮件中证实，“这些微型化的Cas13蛋白表现出与野生型Cas13相似的完全活性，这些接受AAV注射的小鼠的血清总胆固醇水平降低到 ...

Scientists removed unnecessary sections of the Cas13 enzyme, ... by carving out unnecessary bits and then using an artificial intelligence platform called AlphaFold2 to visualize the structure of ...

RNA gene scissors (CRISPR-Cas13) are gaining significant attention as a next-generation gene therapy with fewer side effects. They can suppress infection by eliminating viral RNA, such as in ...

A team led by Professor Won Do Heo from the Department of Biological Sciences, KAIST, has developed a pioneering technology ...

To create REPAIR, the researchers systematically profiled the CRISPR-Cas13 enzyme family for potential “editor” candidates. (Unlike Cas9, the Cas13 proteins target and cut RNA; see infographic in ...

Many of the world's most common or deadly human pathogens are RNA-based viruses -- Ebola, Zika and flu, for example -- and most have no FDA-approved treatments.