Human extracellular matrices can be edited in their composition using the CRISPR/Cas9 system, leading to materials exhibiting tailored regenerative capacities.

Early in cartilage development, the tissue is highly cellular, so significant changes in cell number or volume would likely have proportional effects on the tissue volume. As sources of matrix ...

We first address the etiopathophysiology of OA and the mechanisms responsible for breakdown of the cartilage extracellular matrix. We then discuss the potential of MSCs for articular cartilage ...

Clinical relevance of engineered cartilage maturation in a randomized multicenter trial for articular cartilage repair. Science Translational Medicine, 2025; 17 (788) DOI: 10.1126/scitranslmed.ads0848 ...

"For the production of one of the components in the cartilage matrix, known as collagen II, the dancing molecules containing the cyclic peptide that activates the TGF-beta1 receptor were even more ...

When the team stripped LCs of the lipid vacuoles, the tissue became more rigid than normal lipo-cartilage and similar in biomechanical properties to the matrix-rich knee cartilage. “This will expand ...