Representative compounds were added to cardiomyocytes in a 1:3 dilution series to determine IC50 values. As before, cardiomyocyte contractions were visualized using the EarlyTox Cardiotoxicity dye ...

More information: Paula Ortiz-Sánchez et al, Loss of SRSF3 in Cardiomyocytes Leads to Decapping of Contraction-Related mRNAs and Severe Systolic Dysfunction, Circulation Research (2019).

Cardiomyocytes, or cardiac muscle cells are the main type of heart cells and act as the motor unit to drive heart contraction and relaxation. Particularly, adult human primary cardiomyocyte is a ...

But in the adult heart, "cardiomyocytes barely divide ... severely impairing heart contraction. To investigate the mechanism through which SRSF3 supports heart contraction, the team compared ...

"The intracellular effects of focused near-infrared femtosecond laser irradiation are shown to cause contraction in cultured neonatal rat cardiomyocytes. By periodic exposure to femtosecond laser ...

Reumers and her colleagues have taken specific types of cells, known as cardiomyocytes, from young rats. In tandem with pacemaker cells, these begin to contract spontaneously, generating a heartbeat ...

The importance of redifferentiation: Proteins responsible for heart muscle contraction (green ... focused on genetically engineered mice whose cardiomyocytes – the cells that make up the ...

But in the adult heart, "cardiomyocytes barely divide ... severely impairing heart contraction. To investigate the mechanism through which SRSF3 supports heart contraction, the team compared ...