Sustained exposure to pathological stress stimulates the heart to hypertrophy, increasing disease and mortality risk. New therapies to blunt this process include targeting enzymes below the cell ...

These include acute or chronic adrenergic stimulation, high-fat (or Western) diets, pressure overload, and myocardial infarction models. Using both physiological and pathological model systems, we are ...

Cardiac hypertrophy is the abnormal enlargement, or thickening, of the heart muscle, resulting from increases in cardiomyocyte size and changes in other heart muscle components, such as ...

Aim Differentiating physiological cardiac hypertrophy from pathology is challenging when the athlete presents with extreme anthropometry. While upper normal limits exist for maximal left ventricular ...

The changes in cardiovascular physiology must be differentiated from the effects of pathology ... and left ventricular hypertrophy, as well as other changes in the left ventricular wall that ...

this contributes to the pathology of the disease by, among other actions, increasing the release of aldosterone. Aldosterone has been shown to cause coronary inflammation, cardiac hypertrophy ...