After 24 hours the Gauvins heard a name they never heard of before and one that dramatically changed their lives — pyruvate carboxylase deficiency. “The doctors said ‘He is going to die.

It does this through the activation of two enzymatic pathways: pyruvate dehydrogenase (PDH) dephosphorylation and acetyl-CoA carboxylase (ACC) conversion. Each of these two pathways is discussed ...