44 Human SH-SY5Y neuroblastoma cells were treated with captopril, enalapril or enalaprilat, or saralasin. In all cases, statistically significant reductions in cell growth were seen over 5 days of ...

However, use of enalapril or captopril was associated with higher mortality compared with ramipril: adjusted hazard ratios (and 95% CIs) were 1.10 (1.04–1.16) for enalapril and 1.13 (1.01–1.26) for ...

enalapril, 0.99; 95% CI ... when only half the full dose of valsartan was added to an evidence-based dose of captopril in patients after myocardial infarction. 7 Collectively, these findings ...

Although controlled clinical trials provide essential information about the efficacy and safety of a drug, the experimental conditions of such trials do not mimic everyday clinical practice.

Similar difficulties in data interpretation arose in post hoc analyses of the Captopril and Thrombolysis Study [38] and Cooperative New Scandinavian Enalapril Survival Study II (CONSENSUS II).

A post hoc analysis of the rate of investigator-reported hospital admissions for either myocardial infarction or heart failure showed that 919 patients in the valsartan group (18.7 percent) had a ...