The most common form of CAH is caused by a deficiency in the enzyme 21-hydroxylase, which is crucial for the production of cortisol and aldosterone. This condition can result in serious health ...

SAN DIEGO - Neurocrine Biosciences, Inc. (NASDAQ:NBIX) has sponsored a supplement in The Journal of Clinical Endocrinology & Metabolism (JCEM) focusing on classic congenital adrenal hyperplasia (CAH), ...

and pharmacokinetics of atumelnant when administered for 12 weeks in people with CAH caused by 21-hydroxylase deficiency. The study enrolled 28 patients across 3 dose cohorts with classic CAH on a ...

Sexual precocity and a testicular mass can result from a Leydig cell tumor or from simple virilizing CAH with ... (17 α-hydroxylase/17, 20 lyase), but no detectable mRNA for P450c21 (21 ...

Approximately 95% of CAH cases are caused by variants of the CYP21A2 gene that leads to deficiency of the enzyme 21-hydroxylase (21-OH). Severe deficiency of this enzyme leads to an inability of the ...