Principal catalysts of the hepatic ifosfamide 4-hydroxylation are CYP3A4 and CYP2C9 enzymes, while CYP3A4 and CYP2B6 have demonstrated the major isoforms in the hepatic N-dechloroethylation ...

We have developed a luminogenic CYP2B6 assay for biochemical CYP2B6 inhibition and for cell-based CYP2B6 induction studies. Here we present the CYP2B6 luminogenic assay characterization and ...

Concomitant phenothiazines, other tranquilizers: reduce dose by 25–50%. Concomitant use or discontinuation of CYP2B6/CYP3A4 inhibitors or inducers: monitor closely and consider dose adjustments ...

One such human enzyme, CYP2B6, disables more than a dozen herbicides, pesticides, and industrial chemicals. For some of these compounds, CYP2B6 works better than natural rice enzymes do.