The primary pharmacokinetic interactions with smoking occur with drugs that are CYP1A2 substrates, such as caffeine, clozapine, fluvoxamine, olanzapine, tacrine, and theophylline. Inhaled insulin ...

为探究 CYP1A2 基因单核苷酸多态性（SNPs）影响，研究人员开展相关研究，发现 T385A 等突变影响酶功能，对个性化医疗意义重大。 在人体这个复杂的 “小宇宙” 里，基因就像一个个精密的 “小开关”，掌控着各种生命活动。其中，单核苷酸多态性（SNPs ...

May be antagonized by phenobarbital, phenytoin, others (may need to increase caffeine dose). Caution with CYP1A2 substrates, inhibitors, or inducers.