对 cyp1a2 的序列研究表明，该酶由 516 个氨基酸组成，具有特定的分子量、等电点、氨基酸组成和稳定性指数等理化性质。 同时，确定了 29 个对 CYP1A2 活性位点腔结构有贡献的氨基酸，它们分布在酶的核心和近端表面，部分氨基酸还与相应配体有直接相互作用。

Drinking alcohol while taking antipsychotics can sometimes lead to drowsiness or sedation. ... “One important enzyme in the liver, called CYP1A2, is involved in metabolizing [breaking down] ...

Nanofractionation platform with parallel mass spec to ID cytochrome CYP1A2 inhibitors. by SLAS (Society for Laboratory Automation and Screening) ...

About half of all people have two copies of the CYP1A2 “fast” variant, making them ‘fast’ caffeine metabolizers. Another 40 percent have just one copy and are ‘slow’ metabolizers, and ...

While you can test blood or saliva for CYP1A2 (which lets you know if you are a fast or slow metabolizer of caffeine), you can make an educated guess by how you feel after drinking coffee, says Prest.