为探究 CYP1A2 基因单核苷酸多态性（SNPs）影响，研究人员开展相关研究，发现 T385A 等突变影响酶功能，对个性化医疗意义重大。 在人体这个复杂的 “小宇宙” 里，基因就像一个个精密的 “小开关”，掌控着各种生命活动。其中，单核苷酸多态性（SNPs ...

人体摄入后，超过95%的咖啡因在肝脏中由细胞色素 P450 1A2酶（简称CYP1A2酶）代谢。每个人代谢咖啡因能力的差异，主要取决于CYP1A2基因多态性[2,3]。

And it’s one gene in particular — CYP1A2 — that appears to strongly influence our body’s sensitivity to caffeine. CYP1A2, the gene, controls an enzyme, also called CYP1A2, that is ...

After a person quits smoking, an important consideration is how quickly the induction of CYP1A2 dissipates. This is particularly important when a patient is hospitalized and abruptly quits smoking.

In the study, about half of the participants had the rs762551 variant of the CYP1A2 gene, a variant that caused them to metabolize caffeine more slowly. This group was determined to be at a higher ...

In a study, the researchers showed that markers of kidney dysfunction were nearly three times higher in heavy coffee drinkers with a variant of the CYP1A2 gene that makes them slow metabolizers of ...

Source: Tech Insider One of those enzymes is called CYP1A2, and it's encoded by the CYP1A2 gene. But another gene called AHR encodes a protein that regulates the amount of CYP1A2 there is in the body.

Specifically, caffeine sensitivity depends partly on a liver enzyme called CYP1A2, which is coded by the CYP1A2 gene. The enzyme is responsible for "inactivating 95 percent of all ingested ...