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CXCL16 基因敲除抑制哮喘气道炎症:机制新探与潜在疗法
CXCL16 基因敲除减轻小鼠气道炎症 :将 CXCL16 基因敲除小鼠和野生型小鼠经气管滴注生理盐水或曲霉提取物 3 周后评估气道炎症。结果显示,基因敲除小鼠的支气管周围和血管周围炎症受到抑制,支气管肺泡灌洗液(BALF)中嗜酸性粒细胞计数减少,Th2 细胞因子(IL-4、IL-5 和 IL-13)和趋化因子(如嗜酸性粒细胞趋化蛋白、CCL4、CCL5、MCP-1 和 ...
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