文章综述了CRISPR（Clustered Regularly Interspaced Short Palindromic Repeats）技术在CAR-T（Chimeric Antigen Receptor T-Cell Immunotherapy）疗法中的应用，通过CRISPR可以提高 ...

编者按：CRISPR技术是一种源自细菌免疫系统的基因编辑工具。它能够精准地识别和切割特定的DNA或RNA序列，就像一把“分子剪刀”。近年来 ...

CRISPR-StAR的出现，标志着CRISPR基因筛选技术向高分辨率、低噪声方向迈出了重要一步，为生命科学和医学领域在复杂体内环境中的基因功能研究开辟 ...

在发表在《自然催化》杂志上的一项研究中，佛罗里达州立大学的科学家们制作了第一张高分辨率的延时图像，显示了当CRISPR-Cas9酶切割DNA链时，镁离子与它相互作用，提供了明确的证据，表明镁在化学键断裂和几乎同时的DNA切割中都起着作用。 被称为CRISPR的 ...

该研究对用于 CRISPR 基因编辑治疗的 Cas 核酸酶 SaCas9 和 AsCas12a 进行了理性工程化改造，设计出了具有最小化免疫原性的 SaCas9 和 AsCas12a 突变体。

今天，一项突破性的研究成果刊登于《新英格兰医学杂志》上：首次有研究团队在短短六个月内开发出了一种个体化CRISPR基因编辑疗法，并成功应用 ...

An illustration of DNA broken into two pieces. A decade after CRISPR started to become a major tool in genetic research, a new generation of scientists is growing up with the technology.

Doctors harvest stem cells from the patient’s bone marrow and then send them off to a lab, where CRISPR is used to turn up the production of another, functional version of haemoglobin.

The first medical treatment that uses Crispr gene editing was authorized Thursday by the United Kingdom. The one-time therapy, which will be sold under the brand name Casgevy, is for patients with ...

CRISPR, or clustered regularly interspaced short palindromic repeats, is a technology researchers use to selectively modify DNA, the carrier of genetic information that the body uses to function ...

Suffering on such an immense scale can appear hopeless. However, a technique called CRISPR gene editing promises to help deal with these issues and many more—and wise regulation can spur it on.