A live bacterial cell assay provides an accurate and rapid means of screening for enzyme activity change resulting from human mutations. Gene-edited mouse models are crucial for disease research ...

James Marsh, Max Planck Institute for Biology “We really need to work out a way to access the majority rather than the model organism minority ... Scientists use CRISPR systems to genetically ...

A study of human tumor cells implanted in mice from the MacPherson Lab at Fred Hutch describes a new way to screen for the ...

In new mouse models of the disease ... To fix the dysferlin mutation, Escobar uses CRISPR-Cas9, which is often described as "gene-editing scissors" and for which a Nobel Prize was awarded in ...

In about a third of patients, the gene for dystrophin has small deletions or single base mutations that render it nonfunctional, which makes this gene an excellent candidate for gene editing.

A new model mouse for the neurodegenerative disorder has helped uncover the protective mechanism of a genetic mutation Figure 1: A micrograph showing inflammatory responses in the cortex of the new ...

CRISPR-Cas9 enzymes can be used to edit genes ... The researchers conducted proof-of-concept experiments in human cells and a mouse model of retinitis pigmentosa, finding that the bespoke enzymes ...

CRISPR-Cas9 enzymes can be used to edit genes ... The researchers conducted proof-of-concept experiments in human cells and a mouse model of retinitis pigmentosa, finding that the bespoke enzymes ...

they became the first to use CRISPR to precisely cut genes in mouse cancer cells. But this is the first time they've applied CRISPR to head and neck cancer. According to Pia and his colleagues ...