A study introduces a CRISPR model that predicts gRNA activity more accurately using chemically synthesized gRNAs. The model ...

Blood 2021; 137(12): 1628–1640), St. Jude Children’s Research Hospital scientists generated a novel CRISPR-induced mouse model of acute erythroid leukemia. The model was developed using ...

Now, however, scientists have developed a series of sophisticated mouse models using CRISPR ('clustered regularly interspaced short palindromic repeats') technology that allows them to ...

A team of medical researchers from the University of Texas Southwestern Medical Center, Case Western Reserve University School of Medicine and ReCode Therapeutics has developed a way to send gene ...

Duke University Medical Center-led research has identified a human-specific DNA enhancer that regulates neural progenitor ...

CRISPR-Cas9 enzymes can be used to edit genes ... The researchers conducted proof-of-concept experiments in human cells and a mouse model of retinitis pigmentosa, finding that the bespoke enzymes ...

In new mouse models of the disease ... To fix the dysferlin mutation, Escobar uses CRISPR-Cas9, which is often described as "gene-editing scissors" and for which a Nobel Prize was awarded in ...

CRISPR gene editing has revolutionized genetics ... DMD-targeting experiments in a humanized mouse model demonstrated 10–40% editing in quadriceps, calf, and heart tissues.

Now, however, Yale scientists have developed a series of sophisticated mouse models using CRISPR (“clustered regularly interspaced short palindromic repeats”) technology that allows them to ...