点击蓝字关注我们【导读】汇集光学筛选可以研究大规模的细胞相互作用、形态学或动力学，但它们尚未利用高度复杂的单细胞分辨转录组读数的力量为分子通路提供信息。2025年3月12日，美国麻省理工学院/哈佛大学的研究团队在期刊《Cell》上发表了题为“Simultaneous CRISPR screening and spatial transcriptomics reveal ...

The company has developed a suite of functional genomic screening technologies, including a CRISPR-Cas9 platform. Horizon’s aim is to help its partners to identify, evaluate and validate targets ...

CRISPR-Cas9 技术的出现，为科学家们提供了强大的基因编辑工具，通过 Pooled loss-of-function screening，能大规模探究基因功能，在研究细胞生长、药物抗性和病毒感染等方面成果显著。将其与单细胞 RNA 测序（scRNA-seq）结合后，可在同一细胞中实现基因抑制与转录组 ...

CRISPR-Cas9 is a powerful gene editing tool that cuts DNA in a precise, directed manner. CRISPR screening uses this technology to enable thousands of genes to be modified and their function ...

Cells use small extracellular vesicles (sEVs) to transfer cargo and chemical messengers to neighboring and distant cells.

Human extracellular matrices can be edited in their composition using the CRISPR/Cas9 system, leading to materials exhibiting tailored regenerative capacities.

Advances in the gene-editing technology known as CRISPR-Cas9 over the past 15 years have yielded important new insights into the roles that specific genes play in many diseases. But to date this ...

Studies on NTLA's gene-edited therapy, nex-z, are progressing well while other pipelines are picking up pace. Stiff competition in the target market is a woe.

CRISPR/Cas9 allows for precise modifications to the genome ... Furthermore, CRISPR is a powerful research tool in regenerative medicine. It enables genetic screening to identify genes involved in ...

ERS Genomics Limited ('ERS'), the CRISPR licensing company, and Jumpcode Genomics ('Jumpcode'), a life science tools company ...

Genetic engineering has revolutionized biomedical research, but optimizing these gene-editing tools remains a challenge. Scientists have now developed a novel approach using an enhanced version of ...

When the CRISPR Cas9 protein is added to a cell along with a piece of guide RNA, the Cas9 protein hooks up with the guide RNA and then moves along the strands of DNA until it finds and binds to a ...