The CD95 protein delivers crucial signals for lymphocyte death, and may also negatively regulate T-lymphocyte activation by preventing the influx of calcium ions from the cell’s exterior.

A new clinical study shows that an inhibitor of Fas ligand (FasL), also called CD95 ligand (CD95L ... role of FasL is to keep cells of the immune system, so called T lymphocytes, short T cells ...

CD95L, which is present in tumor endothelia, interacts with CD95 receptors present on activated T cells, thereby triggering apoptotic death of the immune cells. Second, CD95L promotes invasive ...