CD8+ T细胞在免疫防御中扮演关键角色，特别是在抗病毒和抗肿瘤免疫反应中。调节CD8+ T细胞的活化与效应功能是提高免疫治疗效果的关键。蛋白磷酸 ...

A groundbreaking study published in Research (2025, DOI: 10.34133/research.0545) has elucidated the molecular mechanisms by which protein phosphatase 2A (PP2A) regulates CD8+ T cell-mediated immune ...

浙江大学医学院研究人员为探究 T 细胞受体 ... 探索 CD8 在工程化高亲和力 TCR 脱靶交叉反应中的作用，以及阐明 TCR-pMHC 相互作用的机械化学基础，为提高基于 TCR 的免疫疗法的安全性和有效性提供理论支持。该研究成果发表于《Cell Research》。 为了深入探究 ...

with the latter inhibiting CD8 T cell function via TP53 UFMylation elicited by exosomal SerpinB9 from multiple myeloma. VDAC2 deficiency elicits uncontrolled IFNγ-induced BAK activation and ...

A recent Cell Reports paper by the Oxenius group (IMB) demonstrates a function of targeted centrosome inheritance during CD8 + T cell division for the generation of memory precursor cells.

Olga Rivera Ballesteros from the Center for Infectious Medicine (CIM) at the Department of Medicine, Huddinge (MedH) is ...

Researchers from the VIB-KU Leuven Center for Cancer Biology, in collaboration with other scientists, have discovered a way to enhance the immune system's ability to fight cancer by reprogramming ...

In conclusion, Tim-3 was characterized as a novel immune checkpoint molecule with pathophysiological significance in respiratory oncology. Its stage-dependent expression dynamics and multimodal ...

we can begin to use them as a tool to regulate how the immune system functions," said Joshi. More information: Eric Fagerberg et al, KLF2 maintains lineage fidelity and suppresses CD8 T cell ...